CHARACTERISTICS OF THE INFLUENCE OF SOME ISOQUINOLINE ALKALOIDS ON THE DYSFUNCTION OF RAT LIVER MITOCHONDRIA UNDER OXIDATIVE STRESS
Abstract
This article examined the effects of 1-(4-dimethylaminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-24) and 1-(4methoxylphenyl)-6,7-dimethoxy-1 ,2,3,4-tetrahydroisoquinoline (F-4) isoquinoline alkaloids on the swelling of rat liver тmitochondria under oxidative stress (OS) conditions and on lipid peroxidation (LPO) induced by Fe2+/citrate OS model in rats was induced by a single oral administration of salt PbCl2 at a dose of 10 mg/kg per day. The inhibitory effect was demonstrated by isoquinoline alkaloids F-24 and F-4 on the swelling of rat liver mitochondria during OS induced-PbCl2 and Fe2+/citratedependent LPO.
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