ВЛИЯНИЕ АЛКАЛОИДА ЗОНГОРИНА НА СКОРОСТЬ МИТОХОНДРИАЛЬНОГО ДЫХАНИЯ И ПРОЦЕССА ОКИСЛИТЕЛЬНОГО ФОСФОРИЛИРОВАНИЯ НОРМАЛЬНОГО И КРАТКОВРЕМЕННОГО СТРЕССА
Ключевые слова:
зонгорин, митохондрии печени, частота дыхания, окислительное фосфорилирование.
Аннотация
Stress sharoitlari normal fiziologik funksiyalarga salbiy ta’sir ko‘rsatishi tufayli hujayra disfunksiyalarining kelib chiqishiga va undagi molekular mexanizmlarning o‘zgarishiga sabab bo‘lmoqda. Hujayralarning ko‘p funksiyali organoidi hisoblanuvchi mitoxondriyalar ATP sintezlashdan tashqari, hujayra fiziologiyasining turli sohalarida muhim rol o‘ynaydi.
Biofaol moddalardan zongorin diterpenoid alkaloidi in vitro sharoitida normal va stress chaqirilgan mitoxondriyalarning nafas olish tezligi va oksidlanishli fosforlanish jarayonlariga faollashtiruvchi ta’sir ko‘rsatdi.
Литература
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2. Dzhakhangirov F.N., Sultankhodzhaev M.N., Tashkhodzhaev B., Salimov B.T. Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship // Chem. Nat. Compd. – 1997. – 33.P.190-202.
3. Dzhakhangirov F.N., Tursunkhodzhaeva F.M., Sultankhodzhaev M.N., Salimov B.T. Spasmolytic activity of diterpenoid alkaloids and their derivatives // Chem. Nat. Comp. – 2013. – 49. P.702-706.
4. Nesterova Yu.V., Povetieva T.N., Suslov N.I., et al. Study of the antipyretic activity of aqueous-alcoholic extracts and diterpene alkaloids obtained from alkaloid-bearing plants // Questions of Biol., Med. and pharma. chemistry. – 2010. – №10. С.44-48 (in Russian language).
5. Nesterova Y.V., Povetieva T.N., Suslov N.I., Semenov A.A., Pushkarskiy S.V. Antidepressant activity of diterpene alkaloids of Aconitum baicalense Turcz // Bull. Exp. Biol. Med. – 2011. – 151. P.425-428.
6. Khan H., Nabavi S.M., Sureda A., Mehterov N., Gulei D., Beridan-Neagoe I., Taniguchi H., Atanasov A.G. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum // Eur. J. Med. Chem. – 2018. – 153. P.29-33.
7. Dyshlovoy S.A., Kudryashova E.K., Kaune M., Makarieva T.N., et al. Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting // Scientific Reports. – 2020. –V.10, № 9764.
8. Nezhevenko V., Yunusov M.S., Yunusov S.Y. Alkaloids of aconitum monticola structure of acomonine // Chem. Nat. Comp. – 1975. – 11. P.400-404.
9. Gornall A. G., Bardiwill C. J., David M. Determination of serum proteins by means of the Biuret reaction // J. Biol/ Chem. –1949 –Vоl. 177. N 2. –P.751-766.
2. Dzhakhangirov F.N., Sultankhodzhaev M.N., Tashkhodzhaev B., Salimov B.T. Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship // Chem. Nat. Compd. – 1997. – 33.P.190-202.
3. Dzhakhangirov F.N., Tursunkhodzhaeva F.M., Sultankhodzhaev M.N., Salimov B.T. Spasmolytic activity of diterpenoid alkaloids and their derivatives // Chem. Nat. Comp. – 2013. – 49. P.702-706.
4. Nesterova Yu.V., Povetieva T.N., Suslov N.I., et al. Study of the antipyretic activity of aqueous-alcoholic extracts and diterpene alkaloids obtained from alkaloid-bearing plants // Questions of Biol., Med. and pharma. chemistry. – 2010. – №10. С.44-48 (in Russian language).
5. Nesterova Y.V., Povetieva T.N., Suslov N.I., Semenov A.A., Pushkarskiy S.V. Antidepressant activity of diterpene alkaloids of Aconitum baicalense Turcz // Bull. Exp. Biol. Med. – 2011. – 151. P.425-428.
6. Khan H., Nabavi S.M., Sureda A., Mehterov N., Gulei D., Beridan-Neagoe I., Taniguchi H., Atanasov A.G. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum // Eur. J. Med. Chem. – 2018. – 153. P.29-33.
7. Dyshlovoy S.A., Kudryashova E.K., Kaune M., Makarieva T.N., et al. Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting // Scientific Reports. – 2020. –V.10, № 9764.
8. Nezhevenko V., Yunusov M.S., Yunusov S.Y. Alkaloids of aconitum monticola structure of acomonine // Chem. Nat. Comp. – 1975. – 11. P.400-404.
9. Gornall A. G., Bardiwill C. J., David M. Determination of serum proteins by means of the Biuret reaction // J. Biol/ Chem. –1949 –Vоl. 177. N 2. –P.751-766.
Опубликован
2024-03-30
Как цитировать
Dilnoza MURATOVA, Dildor MAHMUDOVA, & Mohinur XUJAYEVA. (2024). ВЛИЯНИЕ АЛКАЛОИДА ЗОНГОРИНА НА СКОРОСТЬ МИТОХОНДРИАЛЬНОГО ДЫХАНИЯ И ПРОЦЕССА ОКИСЛИТЕЛЬНОГО ФОСФОРИЛИРОВАНИЯ НОРМАЛЬНОГО И КРАТКОВРЕМЕННОГО СТРЕССА. Вестник УзМУ, 3(3.1), 75-78. https://doi.org/10.69617/uzmu.v3i3.1.1716
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