ASSESSMENT OF BIOENERGETIC PROCESSES IN MITOCHONDRIA IN IN VIVO MODELS OF PARKINSON'S DISEASE
Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease associated with movement disorders [1]. Although general treatment measures for PK have not been fully developed, some progress has been made in the symptomatic treatment of the disease. The heterogeneity of PK due to the age of onset and the causes of its origin requires the diversity of models that fully reveal the characteristics of the disease. One of the priority tasks during experiments is to choose and create models that can fully reveal all the signs of clinical PK. Currently, animal models are the best tool for studying the pathogenesis of PK. During our experiments, methods of creating an in vivo model of Parkinson's disease in animals and correctly evaluating the motor movements occurring in the models were considered.
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